Broncos vs 49ers injury report

As of 4 October 2026, both the Denver Broncos and the San Francisco 49ers have released their final injury reports heading into their highly anticipated Week 5 clash. The Broncos are dealing with significant concerns in their secondary, as starting cornerback Pat Surtain II is officially listed as questionable due to a lingering hamstring strain sustained during Wednesday’s practice. Additionally, Denver’s offensive line remains thin, with right tackle Mike McGlinchey ruled out for Sunday’s game following a knee injury. On the other side, the San Francisco 49ers are managing the health of their star playmakers. Running back Christian McCaffrey has been cleared to play after missing the previous two weeks with an Achilles issue, providing a major boost to the offense. However, the team will be without tight end George Kittle, who was downgraded to out on Friday after failing to clear concussion protocol. Both coaching staffs are currently finalizing their active rosters, with game-time decisions expected for several depth players across both defensive units as they prepare for the afternoon kickoff.