Arizona cardinals vs 49ers practice report

On 26 September 2026, the Arizona Cardinals and San Francisco 49ers released their final practice reports ahead of their pivotal Week 4 divisional matchup. The Cardinals’ report highlighted concerns regarding their secondary, as starting cornerback Sean Murphy-Bunting was limited throughout the week due to a lingering hamstring issue, leaving his status for Sunday’s game as questionable. Meanwhile, the 49ers’ practice report indicated a significant boost for their offense, with star running back Christian McCaffrey participating in full capacity for the second consecutive day, signaling his return to the active roster after a brief injury hiatus. San Francisco’s defensive line also saw positive developments, as defensive end Nick Bosa was removed from the injury report entirely after managing a minor ankle sprain earlier in the week. Both teams held their final walkthroughs on Friday, focusing on situational drills and red-zone efficiency. With both squads looking to establish dominance in the NFC West, the health of these key playmakers remains the primary narrative heading into the weekend kickoff.